Resources

Connective Tissue Diseases

Novel Multiplex Measurement of Macromolecules Binding To A Solid Phase Using Photonic Microring Sensors
Applications For Autoimmunity


Immunogenicity

Detection of Isotype of Anti-Adalimumab Antibodies using a Multiplex Photonic Ring Immunoassay
The present study shows the performance characteristics of a human anti-Adalimumab Multi-Tier Anti-Drug Antibody (MT-ADA) assay. This is a multiplex assay that determines the isotype and IgG subclass of ADA in a single run, including IgG4. The sensitivity and free drug tolerance exceed FDA guidelines.

Detection of Isotype of Anti-Infliximab Antibodies using a Multiplex Photonic Ring Immunoassay
The present study shows the performance characteristics of a human anti-Infliximab Multi-Tier Anti-Drug Antibody (MT-ADA) assay. This is a multiplex assay that determines the isotype and IgG subclass of ADA in a single run, including IgG4. The sensitivity and free drug tolerance exceed FDA guidelines.

Detection of Anti-Drug Antibodies in Rabbits with a Multiplex Photonic Ring Immunoassay
The present study shows the performance characteristics of a Rabbit Multi-Tier Anti-Drug Antibody (rMT-ADA) assay. This is a multiplex assay that measures the isotype of anti-drug antibodies (ADA) in a single run. The sensitivity and free drug tolerance exceed FDA guidelines.

Emerging Biosensing Approaches for microRNA Analysis.

Graybill RM, Bailey RC. Anal Chem, 2016 Jan 5;88(1):431-50.


Development and validation of an immunosensor for monocyte chemotactic protein 1 using a silicon photonic microring resonator biosensing platform

Enrique Valera, Winnie W. Shia, and Ryan C. Bailey. Clinical Biochemistry.  2016, Volume 49, Issues 1–2, Pages 121–126.


Rapid, Multiplexed Phosphoprotein Profiling Using Silicon Photonic Sensor Arrays

James H. Wade, Aurora T. Alsop, Nicholas R. Vertin, Hongwei Yang, Mark D. Johnson, and Ryan C. Bailey. ACS Cent. Sci. 2015, 1 (7):374–382.


Magnetically-actuated, bead-enhanced silicon photonic immunosensor.

Valera E, McClellan MS, Bailey RC. Anal Methods. 2015 Oct 21;7(20):8539-8544.


High-Q optical sensors for chemical and biological analysis.

Luchansky MS, and Bailey RC. Anal Chem. 2012, 84(2):793-821.


An organophosphonate strategy for functionalizing silicon photonic biosensors.

Shang J, Cheng F, Dubey M, Kaplan JM, Rawal M, Jiang X, Newburg DS, Sullivan PA, Andrade RB, Ratner DM. Langmuir. 2012, 28(6):3338-44.


Label-free virus detection using silicon photonic microring resonators.

McClellan MS, Domier LL, Bailey RC. Biosens Bioelectron. 2012, 31(1):388-92.


Label-free, multiplexed biomolecular analysis using arrays of silicon photonic microring resonators.

Washburn A.L., Luchansky MS., McClellan MS., and Bailey RC. 2012, Procedia Eng.


Isothermal Discrimination of Single-Nucleotide Polymorphisms via Kinetic Desorption and Label-Free Detection of DNA using Silicon Photonic Microring Resonator Arrays.

Qavi AJ., Mysz TM., and Bailey RC. Anal Chem, 2011, 83(17):6827-33.


Anti-DNA:RNA Antibodies and Silicon Photonic Microring Resonators: Increased Sensitivity for Multiplexed microRNA Detection.

Qavi AJ, Kindt JT, Gleeson MA, and Bailey RC, Anal Chem, 2011, 83, 5949-56.


Multiplexed inkjet functionalization of silicon photonic biosensors.

Kirk JT, Fridley GE, Chamberlain JW, Christensen ED, Hochberg M, Ratner DM. Lab Chip. 2011, 11(7):1372-7.


Label-Free, Multiplexed Determination of Aptamer and Antibody Capture Agent Binding Affinities Using Silicon Photonic Microring Resonator Arrays and Implications for Sensitive Biomolecule Detection.

Byeon, J.-Y and Bailey RC, Analyst, 2011, 136(17):3430-3.


Sensitive on-chip detection of a protein biomarker in human serum and plasma over an extended dynamic range using silicon photonic microring resonators and sub-micron beads.

Luchansky MS, Washburn AL, McClellan MS, and Bailey RC, Lab Chip, 2011, 11, 2042-2044.


DNA-Encoding to Improve Performance and Allow Parallel Evaluation of the Binding Characteristics of Multiple Antibodies in a Surface-Bound Immunoassay Format.

Washburn A.L, Gomez J, and Bailey R.C. Anal Chem, 2011, 83, 3572-3580.


Silicon photonic microring resonator arrays for scalable and multiplexable bioanalysis.

Luchansky M.S., Washburn AL, Qavi A.J, Kindt JT, McClellan MS, and Bailey RC, Proc SPIE, 2011, 7888, 788802.


Photonics-on-a-Chip: Recent Advances in Integrated Waveguides as Enabling Detection Elements for Real-World. Lab-on-a-Chip Biosens Applicatios.

Washburn AL,  and Bailey RC. Analyst, 2011, 136, 227-236.


Multiplexed evaluation of capture agent binding kinetics using arrays of silicon photonic microring resonators.

Byeon J-Y, and Bailey RC. Analyst, 2011, 136, 3430-3433.


Sizing up the Future of MicroRNA Analysis.

Qavi AJ, Kindt JT, and Bailey RC, Anal Bioanal Chem, 2010, 398, 2535-2549.


Efficient Bioconjugation of Protein Capture Agents to Biosensor Surfaces Using Aniline-Catalyzed Hydrazone Ligation.

Byeon J.-Y, Limpoco FT, and Bailey RC, Langmuir, 2010, 26, 15430-15435.


Label-Free Biosensor Arrays based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation.

Iqbal M., Gleeson M.A., Spaugh B., Tybor F., Gunn W.G, Hochberg M, Baehr-Jones T, Bailey R.C, and. Gunn LC. J. Sel. Topics Quantum Electron., 2010, 16, 654-661.


Quantitative Multiplexed Detection of Five Protein Biomarkers Using Arrays of Silicon Photonic Microring Resonators.

Washburn AL, Luchansky MS, Bowman AL, and Bailey RC, Anal. Chem., 2010, 82, 69-72.


Characterization of the Evanescent Field Profile and Bound Mass Sensitivity of a Label-Free Silicon Photonic Microring Resonator Biosensing Platform.

Luchansky MS, Washburn AL, Martin TA, Iqbal M, Gunn LC, and Bailey RC, Biosens  Bioelectron, 2010, 26(4):1283-91.


Multiplexed Detection and Label-Free Quantitation of MicroRNAs Using Arrays of Silicon Photonic Microring Resonators.

Qavi A.J. and Bailey R.C.  Angew. Chem. Intl. Ed., 2010, 49, 4608-4611.


Silicon Photonic Microring Resonators for Quantitative Cytokine Detection and T-cell Secretion Analysis.

Luchansky MS, and Bailey RC, Anal. Chem., 2010, 82, 1975-1981.


New Multiparameter Bioanalytical Technologies for Applications in Personalized Medicine, Drug Discovery, and Fundamental Biology.

Bailey RC, Bioanal, 2009, 1, 1043-1047.


Label-Free Technologies for Multiparameter Biological Analysis.

Qavi AJ, Byeon J-Y, Washburn AL, and Bailey RC, Anal Bioanal Chem, 2009, 394, 121-135.


Label-free quantitation of a cancer biomarker in complex media using silicon photonic microring resonators.

Washburn AL, Gunn LC, Bailey RC. Anal Chem. 2009, 81(22):9499-506.


A Robust Silicon Photonic Platform for Multiparameter Biological Analysis.

Bailey R.C., Washburn A.L., Qavi AJ, Iqbal M, Gleeson MA, Tybor F, and Gunn LC.Proc. SPIE, 2009, 7220.

System

Maverick Detection System

15 Minute Universal Multiplex Assay Platform


Immunogenicity

Detection of all ADA subclass and isotypes, including monovalent IgG4, on a Multiplex Photonic Ring Immunoassay

Are you sure your ELISA isn’t missing something?


Connective Tissue Diseases

Application of a Novel Anti-Nuclear Antibody Multiplex Test Using Fingerstick and Venous Whole Blood in a Rheumatology Clinic

Presented at the 2016 ACR/ARHP Annual Meeting, November 11–15, 2016, Washington D.C.

Near Patient Anti-Nuclear Antibody Multiplex Testing Using Whole Blood for the Diagnosis of Connective Tissue Diseases in a Tertiary Care Center

Presented at the 2016 ACR/ARHP Annual Meeting, November 11–15, 2016, Washington D.C.

Characterization of Anti-Nuclear Antibody (ANA) Signatures in Murine Models of Lupus Using Genalyte Maverick Technology

Presented at the 2015 ACR/ARHP Annual Meeting, November 6–11, 2015, San Francisco CA

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