Our Technology

The Maverick Detection System

The Maverick Detection System performs real-time detection of macromolecules in crude samples using biologically functionalized silicon photonic biosensors lithographically printed on disposable silicon chips. These biosensors are individually functionalized with unique probe molecules and are individually interrogated  making highly multiplexed analysis possible. As a sample flows over the chip, the probes on the sensors bind with their corresponding ligands. This binding results in a localized change in refractive index on the sensor surface; this change is directly proportional to analyte concentration.

The continuous monitoring of the refractive index change enables real-time detection without the need for a tag, label, or reporter molecule. No incubations are required, and all reagent additions and wash steps are performed automatically by the instrument. Maverick results are available in 10-30 minutes depending on the type of assay performed.

Easy To Use

Simple and Easy To Use

Small Sample Volume

Small Sample Volume

Wide Range

Wide Dynamic Range


Highly Multiplex

Silicon Photonics Biosensor Technology

Silicon photonics is a rapidly emerging field that has allowed optical devices to leverage the massive infrastructure  investments made by the semiconductor industry for microprocessor and memory markets.  By utilizing the same foundries and processes involved in manufacturing digital electronics, high-volume production of  high-quality biosensing devices is possible.

Each biosensor is designed to trap and circulate  light from a laser around the perimeter of a device known as a ring-resonator.  Each sensor is placed adjacent to a linear waveguide on the chip’s surface that directs light from a laser, past the ring-resonator, and on to a photodetector.  As light traverses the linear waveguide each ring-resonator will trap a single wavelength, producing a “notch” in the wavelength spectrum received at the photodetector.  The formation of biological complexes on the sensor surface causes the refractive index around the resonator to change, which in turn causes a longer wavelength of light to be trapped and the “notch” to move.  The degree of movement of the “notch” is directly proportional to the total mass of bound molecules per unit surface area. During an assay, continuous monitoring of the sensor return spectrum leads to measurement of wavelength shift in resonance peaks, which qualitatively and quantitatively represents reaction dynamics.

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